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Acupuncture for the management of dry eye disease

《医学前沿（英文）》 2022年 第16卷 第6期   页码 975-983 doi: 10.1007/s11684-022-0923-4

摘要： The effectiveness of using acupuncture for dry eye disease (DED) is controversial. Thus, this systematic review investigated the effectiveness and feasibility of using acupuncture for DED in accordance with the 2020 PRISMA statement. The outcomes of interests were (1) to evaluate the efficacy of acupuncture in improving the ocular surface disease index (OSDI), Schirmer I test score, and tear breakup time from baseline to the last follow-up; (2) to determine possible complications of using acupuncture; and (3) to investigate the superiority of acupuncture over other commonly used treatments for DED. Data from 394 patients were collected. Results showed that acupuncture significantly prolonged the tear breakup time (P < 0.0001), significantly increased the Schirmer I test score ( P < 0.0001), and significantly reduced the OSDI ( P < 0.0001) from baseline to the last follow-up. Compared with the control group, the acupuncture group had significantly greater Schirmer I test score ( P < 0.0001), significantly longer tear breakup time ( P = 0.0004), and significantly lower OSDI (P = 0.002). These results suggest that acupuncture is effective and feasible in improving symptoms and signs of DED. No severe adverse effects of acupuncture were observed.

关键词： dry eye disease     xerophthalmus     acupuncture    

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promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial cells in dryeye disease

《医学前沿（英文）》 2023年 第17卷 第4期   页码 781-795 doi: 10.1007/s11684-023-0986-x

摘要： Tear film hyperosmolarity plays a core role in the development of dry eye disease (DED) by mediating the disruption of ocular surface homeostasis and triggering inflammation in ocular surface epithelium. In this study, the mechanisms involving the hyperosmolar microenvironment, glycolysis mediating metabolic reprogramming, and pyroptosis were explored clinically, in vitro, and in vivo. Data from DED clinical samples indicated that the expression of glycolysis and pyroptosis-related genes, including PKM2 and GSDMD, was significantly upregulated and that the secretion of IL-1β significantly increased. In vitro, the indirect coculture of macrophages derived from THP-1 and human corneal epithelial cells (HCECs) was used to discuss the interaction among cells. The hyperosmolar environment was found to greatly induce HCECs’ metabolic reprogramming, which may be the primary cause of the subsequent inflammation in macrophages upon the activation of the related gene and protein expression. 2-Deoxy-d-glucose (2-DG) could inhibit the glycolysis of HCECs and subsequently suppress the pyroptosis of macrophages. In vivo, 2-DG showed potential efficacy in relieving DED activity and could significantly reduce the overexpression of genes and proteins related to glycolysis and pyroptosis. In summary, our findings suggested that hyperosmolar-induced glycolytic reprogramming played an active role in promoting DED inflammation by mediating pyroptosis.

关键词： dry eye disease     glycolytic reprogramming     pyroptosis     inflammation     2-DG    

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Development of a novel hand−eye calibration for intuitive control of minimally invasive surgical robot

《机械工程前沿（英文）》 2022年 第17卷 第3期 doi: 10.1007/s11465-022-0698-y

摘要： Robotic-assisted surgical system has introduced a powerful platform through dexterous instrument and hand−eye coordination intuitive control. The knowledge of laparoscopic vision is a crucial piece of information for robot-assisted minimally invasive surgery focusing on improved surgical outcomes. Obtaining the transformation with respect to the laparoscope and robot slave arm frames using hand−eye calibration is essential, which is a key component for developing intuitive control algorithm. We proposed a novel two-step modified dual quaternion for hand−eye calibration in this study. The dual quaternion was exploited to solve the hand−eye calibration simultaneously and powered by an iteratively separate solution. The obtained hand−eye calibration result was applied to the intuitive control by using the hand−eye coordination criterion. Promising simulations and experimental studies were conducted to evaluate the proposed method on our surgical robot system. We extensively compared the proposed method with state-of-the-art methods. Results demonstrate this method can improve the calibration accuracy. The effectiveness of the intuitive control algorithm was quantitatively evaluated, and an improved hand−eye calibration method was developed. The relationship between laparoscope and robot kinematics can be established for intuitive control.

关键词： minimally invasive surgery     hand−eye calibration     intuitive control     surgical robot     dual quaternion    

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视觉假体：技术和社会经济挑战 Perspective

John B. Troy

《工程（英文）》 2015年 第1卷 第3期   页码 288-291 doi: 10.15302/J-ENG-2015080

摘要：

视觉假体目前已经进入临床市场。最初，视觉假体用来治疗因视网膜色素变性(RP) 导致失明的患者。2015年7月下旬， 视网膜假体首次用于治疗干性年龄相关性黄斑变性。视网膜假体适用于治疗光感受器细胞受损而其他大部分视网膜神经元完好的疾病。而对视网膜输出功能完全丧失的眼部疾病，则需要植入与视觉中枢进行接口的假体类型。目前正在研发的中枢视觉假体的代表是视皮层假体。本文探讨了视觉假体所面临的技术方面和社会经济方面的挑战。

关键词： 神经假体     视觉     眼部疾病     功能恢复     康复    

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Application of cable-supported spatial grid in dry coal shed

XING Haidong, HAO Jiping, XU Guobin

《结构与土木工程前沿（英文）》 2008年 第2卷 第1期   页码 26-29 doi: 10.1007/s11709-008-0008-8

摘要： This paper presented a new structural style cable-supported spatial grid, which was applied in large span dry coal sheds. The influence of configuration of cable on the force of cable and beam, the ratio of beam force to cable force and the deflection of span was investigated, and a rational configuration of cable was obtained. The results show that the cable-supported spatial grid can maximize the use of material strength, and have the advantages of low usage of steel, large span and sufficient headroom.

关键词： dry     material strength     low     rational configuration     influence    

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Influence of HS and NH on biogas dry reforming using Ni catalyst: a study on single and synergetic effect

《环境科学与工程前沿（英文）》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1632-1

摘要：

● NH3 in biogas had a slight inhibitory effect on dry reforming.

关键词： Biogas     Dry reforming     Sulfur poisoning     Ammonia     Synergetic effect     Hydrogen    

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Characteristics of pollutants behavior in a stormwater constructed wetland during dry days

Jianghua YU, Kisoo PARK, Youngchul KIM

《环境科学与工程前沿（英文）》 2012年 第6卷 第5期   页码 649-657 doi: 10.1007/s11783-012-0426-7

摘要： A stormwater wetland treating non-point source pollution (NPS) from a 64 ha agricultural watershed was monitored over a period of five months. The results indicated that pH and dissolved oxygen (DO) were increased in the wetland due to the algal growth. The highest total suspended solids (TSS) concentration was observed in the aeration pond due to the resuspension of solids, decreased in the wetland. The respective decreases in total nitrogen (TN) and total kjeldahl nitrogen (TKN) were 15.9% and 28.7% on passing through the wetland. The nitrate and ammonia were increased by 45.4% and decreased by 79.9%, respectively. These variations provided strong evidence for the existence of nitrification. The total phosphorus (TP) and phosphate had respective reductions of 52.3% and 58.2% over the wetland. The total chemical oxygen demand (TCOD) and soluble chemical oxygen demand (SCOD) were also decreased. Generally, the TN, TP and phosphate removal efficiencies were positive. These positive removal efficiencies were mainly due to microbial activities, uptake by plants, and chemical precipitation at high pH. Negative removal efficiencies can be caused by continuous rainfall activities, with short antecedent dry days (ADDs) and unstable hydraulic conditions, some other biogeochemical transformations and algal growth also being important parameters.

关键词： constructed stormwater wetland     dry days     nitrification and denitrification     pollutants characteristic    

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Seismic behavior of cantilever wall embedded in dry and saturated sand

Sanku KONAI, Aniruddha SENGUPTA, Kousik DEB

《结构与土木工程前沿（英文）》 2020年 第14卷 第3期   页码 690-705 doi: 10.1007/s11709-020-0615-6

摘要： The embedded cantilever retaining walls are often required for excavation to construct the underground facilities. Significant numbers of numerical and experimental studies have been performed to understand the behavior of embedded cantilever retaining walls under static condition. However, very limited studies have been conducted on the behavior of embedded retaining walls under seismic condition. In this paper, the behavior of a small scale model embedded cantilever retaining wall in dry and saturated sand under seismic loading condition is investigated by shake table tests in the laboratory and numerically using software FLAC2D. The embedded cantilever walls are subjected to sinusoidal dynamic motions. The behaviors of the cantilever walls in terms of lateral displacement and bending moment are studied with the variation of the two important design parameters, peak amplitude of the base motions and excavation depth. The variation of the pore water pressures within the sand is also observed in the cases of saturated sand. The maximum lateral displacement of a cantilever wall due to seismic loading is below 1% of the total height of the wall in dry sand, but in case of saturated sand, it can go up to 12.75% of the total height of the wall.

关键词： embedded cantilever wall     shake table test     FLAC2D     seismic loading     saturated and dry sand    

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Performance of vertical axis water turbine with eye-shaped baffle for pico hydropower

Zhuohuan HU, Dongcheng WANG, Wei LU, Jian CHEN, Yuwen ZHANG

《能源前沿（英文）》 2022年 第16卷 第4期   页码 683-696 doi: 10.1007/s11708-020-0689-9

摘要： A series of inline pico hydropower systems, which could be used in confined space, especially for water distribution networks (WDNs), was designed and investigated. The turbine with an eye-shaped vertical water baffle was developed to evaluate the hydraulic performance. A three-dimensional dynamic mesh was employed and the inlet velocity was considered as the inlet boundary condition, whereas the outlet boundary was set as the outflow. Then, numerical simulations were conducted and the standard turbulence model was found to be the best capable of predicting flow features through the comparison with the experimental results. The effects of the opening diameter of the water baffle and installation angle of the rotor on the flow field in the turbine were investigated. The results suggested that the water baffle opening at = 30 mm and the rotor at a 52° angle could achieve the highest efficiency of 5.93%. The proper eye-shaped baffle not only accelerates the fluid flow and generates positive hydrodynamic torque, but also eliminates the flow separation. The scheme proposed in this paper can be exploited for practical applications in the water pipelines at various conditions and power requirements.

关键词： vertical axis water turbine     eye-shaped     vertical water baffle     pico hydropower    

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Use of dry yeast cells as a cheap nitrogen source for lactic acid production by thermophilic

Kim Yng Ooi, Jin Chuan Wu

《化学科学与工程前沿（英文）》 2015年 第9卷 第3期   页码 381-385 doi: 10.1007/s11705-015-1534-2

摘要： Dry yeast cells (DYC) were used as a cheap nitrogen source to replace expensive yeast extract (YE) for L-lactic acid production by thermophilic . Cassava starch (200 g·L ) was converted to L-lactic acid by simultaneous saccharification and fermentation using WCP10-4 at 50 °C in the presence of 20 g·L of DYC, giving 148.1 g·L of L-lactic acid at 27 h with a productivity of 5.5 g·L ·h and a yield of 92%. In contrast, 154.4 g·L of lactic acid was produced at 24 h with a productivity of 6.4 g·L ·h and a yield of 96% when equal amount of YE was used under the same conditions. Use of pre-autolyzed DYC at 50 °C for overnight slightly improved the lactic acid titer (154.5 g·L ) and productivity (7.7 g·L ·h ) but gave the same yield (96%).

关键词： L-lactic acid     thermophilic strain     Bacillus coagulans     dry yeast cells     autolysis     fermentation    

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Laboratory study on high-temperature adsorption of HCl by dry-injection of Ca(OH)

Junjun TAN,Guohua YANG,Jingqiao MAO,Huichao DAI

《环境科学与工程前沿（英文）》 2014年 第8卷 第6期   页码 863-870 doi: 10.1007/s11783-013-0618-9

摘要： Combustion-generated hydrogen chloride (HCl) is considered to be a very hazardous acid gaseous pollutant. This paper presents a laboratory study on the dry adsorption of HCl. The experiments were conducted in a dual-layer granular bed filter, at gas temperatures of 500°C–700°C and (Ca)/ (Cl)molar ratios of 1.0–5.0 using the silver nitrate titration method by dry adsorbent powders Ca(OH) . Mainly, the adsorption efficiency of HCl and utilization efficiency of Calcium were studied, by varying relevant factors including (Ca)/ (Cl), temperature, feeding method, water vapor and CO . With a relatively higher HCl concentration of 1000 ppm, the experimental results revealed that 600°C may be the optimum temperature for HCl adsorption when optimum (Ca)/ (Cl) was 2.5 in our tests. The results also demonstrated that the feeding at a constant pressure was more effective, and the HCl adsorption efficiency could rapidly reach over 90% with (Ca)/ (Cl) = 2.5 at 600°C. Furthermore, the HCl adsorption efficiency was found to be slightly promoted by water vapor, while could be impeded by CO , and the utilization efficiency of calcium could be up to 74.4% without CO , while was only 36.8% with CO when (Ca)/ (Cl) was 2.5 at 600°C.

关键词： acid gas HCl     Ca(OH)2     dry adsorption     high temperature     dual-layer granular bed filter    

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A decoupled method to identify affecting mechanism of crosswind on performance of a natural draft dry

Weiliang WANG, Junfu LYU, Hai ZHANG, Qing LIU, Guangxi YUE, Weidou NI

《能源前沿（英文）》 2020年 第14卷 第2期   页码 318-327 doi: 10.1007/s11708-019-0627-x

摘要： The natural draft dry cooling tower (NDDCT) has been increasingly used for cooling in power generation in arid area. As crosswind affects the performance of a NDDCT in a complicated way, and the basic affecting mechanism is unclear, attempts have been made to improve the performance of a NDDCT based on limited experiences. This paper introduces a decoupled method to study the complicated crosswind effects on the inlet and outlet of a NDDCT separately by computational fluid dynamics (CFD) modeling and hot state experiments. Accordingly, the basic affecting mechanism of crosswind on the NDDCT performance is identified. Crosswind changes the inlet flow field of a NDDCT and induces mainstream vortices inside the tower, so as to degrade the ventilation. Besides, low crosswind deflects the upward plume at the outlet to further degrade the ventilation, while high crosswind induces the low pressure area at the outlet to reduce the ventilation degradation.

关键词： affecting mechanism     crosswind     decoupled method     mainstream vortices     natural draft dry cooling tower (NDDCT)     degradation    

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Sensory innervation of the anterior eye segment in rats: a retrograde tracing study

Haixia LIU MD , Zhiwang LI MD , Min YANG MD , Xiang TIAN MS , Chaoying LI PhD , Lei PEI PhD ,

《医学前沿（英文）》 2009年 第3卷 第3期   页码 352-356 doi: 10.1007/s11684-009-0065-y

摘要： This study aimed to investigate the sensory innervation of the anterior eye segment in rats by retrograde tracing with 1,1-dioleyl-3,3,3,3-tetrameth-ylindocarbocyanine, 4-chlorobenesulfonate (FAST Dil) injected into the anterior chamber. In our study, the sensory innervation of distinct elements of the anterior segment of the rat’s eye, i.e. the cornea, ciliary body, iris, and trabecular meshwork, were studied by retrograde tracing using FAST Dil as a tracer. FAST Dil was injected into the anterior chambers of the rat’s eyes. The animals were sacrificed at different time points, i.e., 2, 3, 4, and 5 days after the injection. FAST Dil localization in trigeminal ganglions was studied with a fluorescent microscope. Two days after FAST Dil injection into the anterior chambers, the cornea, the ciliary body, the iris, and the trabecular meshwork were heavily labeled. Neurons in the ipsilateral trigeminal ganglion were also consistently labeled. The number of labeled cells increased over time until 4 days after FAST Dil injection. FAST Dil-labeled neurons could be divided into two parts. Most of the Dil-labeled neurons were concentrated in a sharp, longitudinal, spindle-like stripe, located in the dorso-medial side of the trigeminal ganglion, approximately two thirds of the dorsal portion. The other part of Dil-labeled neurons scattered laterally to the stripe, but just in one third of the dorsal region. Thus, with our preliminary results, we conclude that the primary afferent sensory neurons innervating the rat’s anterior eye segments aggregate in the dorso-medial part of the ipsilateral trigeminal ganglion. It is feasible to identify them using retrograde tracing with FAST Dil anterior chamber injection.

关键词： trigeminal ganglion     retrograde tracing    

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Assessment of metals in dry-toilet collected matters from suburban areas of Ulaanbaatar, Mongolia, using

Xuan LIU,Zifu LI,Eric BOSC,Heinz-Peter MANG

《环境科学与工程前沿（英文）》 2014年 第8卷 第5期   页码 710-718 doi: 10.1007/s11783-013-0592-2

摘要： Dry-toilet collected matter (DCM) from traditional dry-toilet pits are a potential health and ecological risk in suburban areas. In this study, the characteristics of metals in DCMs from suburban areas of Ulaanbaatar were surveyed. The results indicate that DCMs contain a high percentage of organic matter and nutrients, while heavy metals are at low levels, which shows good agricultural potential. The concentration ranges of Cr, Cu, Hg, Ni, Pb, and Zn were 11±5, 46±9, 0.08±0.05, 9±3, 17±9, and 338±86 mg·kg , respectively. The concentration of Cd was below 0.5 mg·kg , and a high positive relation was shown between chromium and nickel concentrations. The heavy metals in DCMs were safe for land application but Zn in DCMs was close to the effects range median (ERM), which is toxic in some cases, such as amphipod bioassays. Because it is mandatory to treat DCMs to reduce pathogens, in the case of heavy metal enrichment and agricultural reuse, composting or pyrolysis are better choices than incineration. Compared with global soil background values, the heavy metals in DCMs showed a low level of ecological risk, but a medium level when compared with Mongolian soil background values. The ecological risk of six heavy metals was in the descending order Hg>Cu>Zn>Pb>Ni>Cr and the contribution rate of Hg exceeded 60%.

关键词： heavy metals     suburban areas     dry-toilet     risk assessment    

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标题 作者 时间 类型 操作

Acupuncture for the management of dry eye disease

期刊论文

promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial cells in dryeye disease

期刊论文

Development of a novel hand−eye calibration for intuitive control of minimally invasive surgical robot

期刊论文

视觉假体：技术和社会经济挑战

John B. Troy

期刊论文

Application of cable-supported spatial grid in dry coal shed

XING Haidong, HAO Jiping, XU Guobin

期刊论文

Influence of HS and NH on biogas dry reforming using Ni catalyst: a study on single and synergetic effect

期刊论文

Characteristics of pollutants behavior in a stormwater constructed wetland during dry days

Jianghua YU, Kisoo PARK, Youngchul KIM

期刊论文

Gerald Fuller：润滑速——缓解干眼症状（2019年9月25日）

2021年04月22日

会议视频

Seismic behavior of cantilever wall embedded in dry and saturated sand

Sanku KONAI, Aniruddha SENGUPTA, Kousik DEB

期刊论文

Performance of vertical axis water turbine with eye-shaped baffle for pico hydropower

Zhuohuan HU, Dongcheng WANG, Wei LU, Jian CHEN, Yuwen ZHANG

期刊论文

Use of dry yeast cells as a cheap nitrogen source for lactic acid production by thermophilic

Kim Yng Ooi, Jin Chuan Wu

期刊论文

Laboratory study on high-temperature adsorption of HCl by dry-injection of Ca(OH)

Junjun TAN,Guohua YANG,Jingqiao MAO,Huichao DAI

期刊论文

A decoupled method to identify affecting mechanism of crosswind on performance of a natural draft dry

Weiliang WANG, Junfu LYU, Hai ZHANG, Qing LIU, Guangxi YUE, Weidou NI

期刊论文

Sensory innervation of the anterior eye segment in rats: a retrograde tracing study

Haixia LIU MD , Zhiwang LI MD , Min YANG MD , Xiang TIAN MS , Chaoying LI PhD , Lei PEI PhD ,

期刊论文

Assessment of metals in dry-toilet collected matters from suburban areas of Ulaanbaatar, Mongolia, using

Xuan LIU,Zifu LI,Eric BOSC,Heinz-Peter MANG

期刊论文